Health Commissioner Cheryl Bettigole said Philadelphia’s average daily case count had dropped to 189 cases per day in the city of more than 1.5 million people. Bettigole said the plunge in infections has been steeper in Philadelphia than elsewhere in the state or the country, making it easier to lift the vaccine mandate for restaurants and other businesses announced in mid-December and that just fully went into effect this month.

“Our goal has always been to the least restrictive as possible while ensuring safety,” she said.

In Provincetown, Massachusetts, a seaside town that became a COVID hot spot with an early outbreak of the delta variant last summer, officials on Tuesday lifted a mask mandate and vaccine requirement for indoor spaces like restaurants and bars. Town Manager Alex Morse said the community of about 3,000 recorded zero active cases last week among Provincetown residents — something that hasn’t happened since the surge following last year’s July 4 celebrations.

“We are learning to live with, and mitigate, the impact of the virus on our community,” Morse said.

COVID-19 infections and hospitalizations have fallen sharply in the US, with the seven-day rolling average for daily new cases dropping from about 453,000 two weeks ago to about 136,000 as of Tuesday, according to data from Johns Hopkins University. Hospitalizations are at levels similar to September, when the US was emerging from the delta variant surge. Almost 65% of Americans are fully vaccinated.

“As a result of all this progress and the tools we now have, we are moving to a time where COVID isn’t a crisis but is something we can protect against and treat,” said Jeff Zients, the White House coronavirus response coordinator.

Walensky said the CDC “will soon put guidance in place that is relevant and encourages prevention measures when they are most needed to protect public health and our hospitals.” She suggested any changes will take into account measures of community transmission, as well as hospitalization rates or other gauges of whether infected people are becoming severely ill. They also would consider available bed space in hospitals.

Several states with indoor mask mandates announced last week they would be lifted in coming weeks, also citing promising numbers.

Two music festivals that draw thousands of people to the California desert town of Indio in April and May, Coachella and Stagecoach, also said this week there will be no vaccination, masking or testing mandates in accordance with local guidelines. Coachella also noted that could change along with COVID conditions.

In Philadelphia, Bettigole said the vaccine mandate helped spur “a very large” increase in pediatric vaccinations, pushing the city way ahead of the national average for first doses among kids ages 5 to 11. More than 53% of Philadelphia residents in that age group have received a first dose, compared to closer to 30% nationally, she said.

Not all businesses plan to immediately change course. Philadelphia Irish sports bar and restaurant O’Neals will keep asking to see customers’ vaccination cards for now, said managing partner Greg “Spoonie” Rand, even though the city is lifting its vaccine mandate.

“Guests are more compliant and employees are more happy for us to continue doing vaccine cards inside,” he said. He thinks vaccinated people will be wary of coming in if the pub stops checking cards.

Walensky said the CDC wants to “give people a break from things like mask-wearing” when circumstances improve, though be able to mask up again if things worsen. She also said there will be instances where people should continue to wear masks even if prevention measures ease. Examples include when individuals have symptoms of COVID-19 or are within 10 days after being diagnosed with it.